PT  - JOURNAL ARTICLE
AU  - Léa Rossi
AU  - Marie-Aude Le Frere-Belda
AU  - Pierre Laurent-Puig
AU  - Bruno Buecher
AU  - Antoine De Pauw
AU  - Dominique Stoppa-Lyonnet
AU  - Geoffroy Canlorbe
AU  - Olivier Caron
AU  - Bruno Borghese
AU  - Chrystelle Colas
AU  - Hélène Delhomelle
AU  - Nathalie Chabbert-Buffet
AU  - Sophie Grandjouan
AU  - Fabrice Lecuru
AU  - Anne-Sophie Bats
TI  - Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome: A French Multicenter Study
AID  - 10.1097/IGC.0000000000000985
DP  - 2017 Jun 01
TA  - International Journal of Gynecologic Cancer
PG  - 953--960
VI  - 27
IP  - 5
4099  - http://ijgc.bmj.com/content/27/5/953.short
4100  - http://ijgc.bmj.com/content/27/5/953.full
SO  - Int J Gynecol Cancer2017 Jun 01; 27
AB  - Background Limited data exist on Lynch syndrome (LS)–related endometrial cancer (EC) features. Amsterdam criteria II, commonly used, have poor sensitivity for detection of LS, which is underdiagnosed.Aim The aim of this study was to describe the clinical and pathological features of LS-related EC among mutation-proven patients.Methods We conducted a retrospective study from 1977 to 2013 in 5 hospitals. The inclusion criteria were patients who had a primary EC associated to LS proven by a germline mutation. We analyzed the clinical data and the pathology of the tumors. The patient management and the survival data were also collected.Results Forty-nine patients (15 MLH1, 20 MSH2, 13 MSH6, 1 PMS2) were included. The mean age at diagnosis was 49.7 (SD, 10.5) years. The median body mass index was 22.6 kg/m2. In 81.4% of cases, EC was the first cancer of the LS spectrum to occur. Endometrioid adenocarcinoma accounted for 89.2% of the EC, the lower uterine segment was involved in 25% of cases, and a synchronous ovarian cancer was present in 21.6% of patients. The tumors were grade 3 in 19.3% of cases and FIGO (International Federation of Gynecology and Obstetrics) stage I in 66.6% of cases. With a median follow-up of 58 months, 3 patients with conservative management developed a recurrence, and no patient died of EC.Conclusions The LS-associated EC is characterized by a young age at onset, a high prevalence of lower uterine segment involvement, and synchronous ovarian cancers. The prognosis of these cancers does not appear different from sporadic tumors.