TY - JOUR T1 - Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome: A French Multicenter Study JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 953 LP - 960 DO - 10.1097/IGC.0000000000000985 VL - 27 IS - 5 AU - Léa Rossi AU - Marie-Aude Le Frere-Belda AU - Pierre Laurent-Puig AU - Bruno Buecher AU - Antoine De Pauw AU - Dominique Stoppa-Lyonnet AU - Geoffroy Canlorbe AU - Olivier Caron AU - Bruno Borghese AU - Chrystelle Colas AU - Hélène Delhomelle AU - Nathalie Chabbert-Buffet AU - Sophie Grandjouan AU - Fabrice Lecuru AU - Anne-Sophie Bats Y1 - 2017/06/01 UR - http://ijgc.bmj.com/content/27/5/953.abstract N2 - Background Limited data exist on Lynch syndrome (LS)–related endometrial cancer (EC) features. Amsterdam criteria II, commonly used, have poor sensitivity for detection of LS, which is underdiagnosed.Aim The aim of this study was to describe the clinical and pathological features of LS-related EC among mutation-proven patients.Methods We conducted a retrospective study from 1977 to 2013 in 5 hospitals. The inclusion criteria were patients who had a primary EC associated to LS proven by a germline mutation. We analyzed the clinical data and the pathology of the tumors. The patient management and the survival data were also collected.Results Forty-nine patients (15 MLH1, 20 MSH2, 13 MSH6, 1 PMS2) were included. The mean age at diagnosis was 49.7 (SD, 10.5) years. The median body mass index was 22.6 kg/m2. In 81.4% of cases, EC was the first cancer of the LS spectrum to occur. Endometrioid adenocarcinoma accounted for 89.2% of the EC, the lower uterine segment was involved in 25% of cases, and a synchronous ovarian cancer was present in 21.6% of patients. The tumors were grade 3 in 19.3% of cases and FIGO (International Federation of Gynecology and Obstetrics) stage I in 66.6% of cases. With a median follow-up of 58 months, 3 patients with conservative management developed a recurrence, and no patient died of EC.Conclusions The LS-associated EC is characterized by a young age at onset, a high prevalence of lower uterine segment involvement, and synchronous ovarian cancers. The prognosis of these cancers does not appear different from sporadic tumors. ER -