@article {BrezisA222, author = {Miriam Rivka Brezis and Shira Peleg Hasson and Eliya Shachar and Dan Grisaro and Ido Laskov and Nadav Michaan and Lyri Adar and Avigail Harpaz and Adi Diner and Bar Levy and Ido Wolf and Tamar Safra}, title = {2022-RA-209-ESGO A retrospective study of ovarian cancer among elderly {\textendash} evaluation and prognosis}, volume = {32}, number = {Suppl 2}, pages = {A222--A223}, year = {2022}, doi = {10.1136/ijgc-2022-ESGO.483}, publisher = {BMJ Specialist Journals}, abstract = {Introduction/Background Half of epithelial ovarian cancer (EOC) are diagnosed above age 65. Women over 70 have higher morbidity and mortality. Our real-life retrospective study evaluates elderly with EOC.Methodology Women above 70 were classified as {\textquoteleft}elderly{\textquoteright} (N=233) (71{\textendash}93), and bellow 70 {\textendash} {\textquoteleft}control cohort{\textquoteright} (N=755) (24{\textendash}70). Treatment schedule used (6{\textendash}8 cycles) were 3-weekly regimen (PC-3W) {\textendash} carboplatin AUC-6 + Paclitaxel 175 mg/m2 on day 1 of a 21-day cycle, and weekly regimen (PC-1W) {\textendash} carboplatin AUC-2 + paclitaxel 80 mg/m2 on days 1, 8, and 15 of a 28-day cycleResults When comparing elderly to control median overall survival (mOS) was 41.26 (33.05{\textendash}63.87) vs. 69.78 (50.07{\textendash}75.01) months respectively (p\<0.0001). No statistical differences were shown when comparing toxicities except for grade 2 anemia {\textendash} 36.49\% vs. 19.67\% respectively (p\<0.0001) and grade 2 alopecia {\textendash} 44.81\% vs. 60.52\% respectively (p\<0.0001). The use of PC-1W vs. PC-3W was 44.29\% vs 47.14\% in the elderly compared to 39.03\% vs. 60.3\% in the control (p\<0.0001). Among the elderly mOS was 57.17 vs. 30.00 months for PC-1W and PC-3W respectively (p = 0.0075). No differences in toxicity were shown, when comparing PC-1W to PC-3W in elderly except for grade 2 alopecia {\textendash} 26.21\% vs. 65.18\% respectively (p\<0.0001), and grade 2 neuropathy {\textendash} 20.19\% vs. 36.61\% respectively (p=0.0119)Abstract 2022-RA-209-ESGO Figure 1 View this table:Abstract 2022-RA-209-ESGO Tabel 1 Abbreviations OS = overall survival, PFS = Progression free survivalConclusion mOS is reduced in elderly, though better than expected, furthermore toxicity is tolerable in elderly. PC-1W was both more abundant and had better mOS in the elderly population. Therefore PC-1W regimen may offer advantages for elderly in terms of tolerance while retaining efficacy.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/32/Suppl_2/A222.3}, eprint = {https://ijgc.bmj.com/content/32/Suppl_2/A222.3.full.pdf}, journal = {International Journal of Gynecologic Cancer} }