PT  - JOURNAL ARTICLE
AU  - Giorgia Dinoi
AU  - Eleonora La Fera
AU  - Stefano Restaino
AU  - Pia Clara Pafundi
AU  - Alessandro Gioè
AU  - Laura Naccarato
AU  - Emilia Palmieri
AU  - Giovanni Scambia
AU  - Francesco Fanfani
TI  - 2022-RA-1346-ESGO Predictive factors for adnexal involvement in Endometrial Cancer, with a focus on FIGO Stage IIIA, an uncommon entity
AID  - 10.1136/ijgc-2022-ESGO.312
DP  - 2022 Oct 01
TA  - International Journal of Gynecologic Cancer
PG  - A146--A147
VI  - 32
IP  - Suppl 2
4099  - http://ijgc.bmj.com/content/32/Suppl_2/A146.2.short
4100  - http://ijgc.bmj.com/content/32/Suppl_2/A146.2.full
SO  - Int J Gynecol Cancer2022 Oct 01; 32
AB  - Introduction/Background To assess the incidence of endometrial cancer (EC) FIGO stage IIIA, and evaluate predictors of adnexal involvement, and its role as prognostic factor of recurrence and death in EC.Methodology Records of all consecutive EC patients who underwent primary surgery between January 2005 and November 2021 at Fondazione Policlinico A. Gemelli, Rome, were retrospectively reviewed. Potential predictive factors of adnexal involvement were assessed by logistic regression models. Overall survival (OS) and recurrence-free survival (RFS) were estimated using Kaplan-Meier method and potential independent prognostic factors assessed by Cox proportional-hazard models.View this table:Abstract 2022-RA-1346-ESGO Table 1 Results 2079 patients were finally included in the study. Of those, 55 were stage IIIA EC (annual incidence 0.11%). Recurrences occurred in 16 out of 55 patients (29.1%), mostly pelvic and lymphatic (43.8% each). Notably, 27/39 (69.2%) who did not recur underwent chemotherapy with external beam radiation therapy. 5-years RFS and OS in stage IIIA were 72.7% and 85.5%, respectively.Overall, 207 patients had adnexal involvement (annual incidence 0.42%), with myometrial infiltration [(MI) OR 1.51, 95% 1.03–2.21; 0.035], isolated and diffuse lymphovascular space invasion [(LVSI) OR 2.51, 95%CI 1.59–3.97; OR 3.27, 95%CI 2.16–4.94; p<0.001, respectively), cervical stromal invasion [(CSI) OR 4.26, 95%CI 3.00–6.05; p<0.001], and instable mismatch repair (iMMR) phenotype (OR 1.96, 95%CI 1.24–3.08; p=0.004) found as independent predictors (Table). Remarkably, adnexal involvement in EC further revealed an independent negative predictive factor of RFS (HR 3.20, 95%CI 1.66–6.18; p=0.001), whilst only a suggestive negative role emerged on OS (HR 1.73, 95%CI 0.93–3.24; p=0.086). Consistently, 5-years RFS and OS were shorter among women with adnexal involvement compared with those without (63.3 vs. 87.5%, and 68.6 vs. 92.9%, p<0.001, respectively).Conclusion Main predictors of adnexal involvement in EC are iMMR phenotype, MI, isolated and diffuse LVSI, and CSI. Although adnexal involvement incidence is low, this may be associated with higher recurrence risk.