RT Journal Article SR Electronic T1 2022-RA-221-ESGO Hysterectomy alone vs. hysterectomy plus sentinel node mapping in endometrial cancer: long-term results from a multi-institutional study JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP A93 OP A93 DO 10.1136/ijgc-2022-ESGO.207 VO 32 IS Suppl 2 A1 Giorgio Bogani A1 Violante Di Donato A1 Andrea Papadia A1 Alessandro Buda A1 Jvan Casarin A1 Fabio Ghezzi A1 Roberto Angioli A1 Francesco Plotti A1 Daniela Luvero A1 Fabio Landoni A1 Pierluigi Benedetti Panici A1 PierAndrea de Iaco A1 Myriam Perrone A1 Flavia Sorbi A1 Simone Ferrero A1 Michel Mueller A1 Francesco Raspagliesi YR 2022 UL http://ijgc.bmj.com/content/32/Suppl_2/A93.1.abstract AB Introduction/Background To compare outcomes after hysterectomy and hysterectomy plus sentinel node mapping (SNM) in endometrial cancer (EC) patients.Methodology This is a retrospective study, collecting data from EC patients treated between 2006 and 2016 in nine referral centers.Results The study population included 398 (69.5%) and 174 (30.5%) patients having hysterectomy and hysterectomy plus SNM. As the results of the adoption of a propensity-score matched analysis, we selected two homogeneous cohorts of patients (150 having hysterectomy only vs. 150 having hysterectomy plus SNM). The execution of sentinel node mapping correlated with longer operative time, but it is not influencing the length of hospital stay and estimated blood loss. Overall severe complication rates were similar between groups (0.7% in the hysterectomy group vs. 1.3% in the hysterectomy plus SNM group; p=1.00). No lymphatic-specific complication occurred. Overall, 12.6% of patients having SNM were diagnosed with disease harboring in their lymph nodes. Adjuvant therapy administration rate was similar between groups. Considering patients having SNM, 4% of patients received adjuvant therapy on the basis of nodal status only; all the other patients received adjuvant therapy on the basis of uterine risk factors. Five-year disease-free (p=0.720) and overall (p=0.632) survival was not influenced by the surgical approach.Conclusion Hysterectomy (with or without SNM) is a safe and effective method for managing EC patients. Potentially, these data support the omission of side-specific lymphadenectomy in case of unsuccessful mapping. Further evidence is warranted to confirm the role of SNM in the era of molecular/genomic profiling.