TY - JOUR T1 - Management of oligometastatic ovarian cancer recurrence during PARP inhibitor maintenance JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1164 LP - 1170 DO - 10.1136/ijgc-2022-003543 VL - 32 IS - 9 AU - Eleonora Palluzzi AU - Claudia Marchetti AU - Serena Cappuccio AU - Giacomo Avesani AU - Gabriella Macchia AU - Maria Antonietta Gambacorta AU - Fabrizio Cocciolillo AU - Giovanni Scambia AU - Anna Fagotti Y1 - 2022/09/01 UR - http://ijgc.bmj.com/content/32/9/1164.abstract N2 - Objective The benefit of surgery and maintenance treatment with PARP inhibitors (PARPi) has been clearly demonstrated in ovarian cancer. Also, the efficacy and safety of stereotactic body radiotherapy has been shown in patients with metastatic, persistent, and recurrent disease. The aim of this study is to evaluate the management of oligometastatic progression during PARPi maintenance treatment.Methods This is an observational, retrospective, single-arm study conducted from June 2017 to December 2020 in patients with recurrent ovarian cancer with oligometastatic progression under PARPi maintenance treatment and receiving surgery or stereotactic body radiotherapy for such recurrence. PARPi treatment was continued until further progression of the disease. The primary objective of the study was the median prolongation of the treatment-free interval-p (without platinum) after local treatment.Results A total of 186 patients with ovarian cancer were treated with PARPi at recurrence. Of these, 30 (16%) developed oligometastatic progression. The median age was 49.5 years (range 35–73). Olaparib, niraparib and rucaparib were administered to 33%, 60%, and 7% of patients, respectively. The median prolongation of the treatment-free interval-p of patients treated with surgery or stereotactic body radiotherapy was 6 and 10 months, respectively (p=0.53). The median treatment-free interval-p of patients treated with surgery or stereotactic body radiotherapy at the time of oligometastatic progression was 32 and 29 months, respectively (p=0.44). At the time of this publication, 50% of patients are still on treatment with PARPi following progression.Conclusions Patients with recurrent ovarian cancer who have oligometastic progression during PARPi maintenance may continue to benefit from PARPi if combined with local treatment.We will provide our data for the reproducibility of this study in other centers if such is requested. The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request. ER -