RT Journal Article
SR Electronic
T1 Management of oligometastatic ovarian cancer recurrence during PARP inhibitor maintenance
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1164
OP 1170
DO 10.1136/ijgc-2022-003543
VO 32
IS 9
A1 Palluzzi, Eleonora
A1 Marchetti, Claudia
A1 Cappuccio, Serena
A1 Avesani, Giacomo
A1 Macchia, Gabriella
A1 Gambacorta, Maria Antonietta
A1 Cocciolillo, Fabrizio
A1 Scambia, Giovanni
A1 Fagotti, Anna
YR 2022
UL http://ijgc.bmj.com/content/32/9/1164.abstract
AB Objective The benefit of surgery and maintenance treatment with PARP inhibitors (PARPi) has been clearly demonstrated in ovarian cancer. Also, the efficacy and safety of stereotactic body radiotherapy has been shown in patients with metastatic, persistent, and recurrent disease. The aim of this study is to evaluate the management of oligometastatic progression during PARPi maintenance treatment.Methods This is an observational, retrospective, single-arm study conducted from June 2017 to December 2020 in patients with recurrent ovarian cancer with oligometastatic progression under PARPi maintenance treatment and receiving surgery or stereotactic body radiotherapy for such recurrence. PARPi treatment was continued until further progression of the disease. The primary objective of the study was the median prolongation of the treatment-free interval-p (without platinum) after local treatment.Results A total of 186 patients with ovarian cancer were treated with PARPi at recurrence. Of these, 30 (16%) developed oligometastatic progression. The median age was 49.5 years (range 35–73). Olaparib, niraparib and rucaparib were administered to 33%, 60%, and 7% of patients, respectively. The median prolongation of the treatment-free interval-p of patients treated with surgery or stereotactic body radiotherapy was 6 and 10 months, respectively (p=0.53). The median treatment-free interval-p of patients treated with surgery or stereotactic body radiotherapy at the time of oligometastatic progression was 32 and 29 months, respectively (p=0.44). At the time of this publication, 50% of patients are still on treatment with PARPi following progression.Conclusions Patients with recurrent ovarian cancer who have oligometastic progression during PARPi maintenance may continue to benefit from PARPi if combined with local treatment.We will provide our data for the reproducibility of this study in other centers if such is requested. The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.