TY - JOUR T1 - Survival impact of histological response to neoadjuvant chemotherapy according to number of cycles in patients with advanced ovarian cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 967 LP - 974 DO - 10.1136/ijgc-2021-003313 VL - 32 IS - 8 AU - Sarah Betrian AU - Martina Aida Angeles AU - Antonio Gil Moreno AU - Bastien Cabarrou AU - Marion Deslandres AU - Gwenael Ferron AU - Eliane Mery AU - Anne Floquet AU - Frederic Guyon AU - Assumpció Pérez-Benavente AU - Emanuela Spagnolo AU - Agnieszka Rychlik AU - Laurence Gladieff AU - Alicia Hernández Gutiérrez AU - Alejandra Martinez Y1 - 2022/08/01 UR - http://ijgc.bmj.com/content/32/8/967.abstract N2 - Objective We sought to evaluate the impact of chemotherapy response score according to the number of cycles of neoadjuvant chemotherapy, on disease-free survival and overall survival, in patients with advanced epithelial ovarian cancer ineligible for primary debulking surgery.Methods This multicenter retrospective study included patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC-IV epithelial ovarian cancer who underwent 3–4 or 6 cycles of a platinum and taxane-based neoadjuvant chemotherapy, followed by complete cytoreduction surgery (CC-0) or cytoreduction to minimal residual disease (CC-1), between January 2008 and December 2015, in four institutions. Disease-free survival and overall survival were assessed according to the histological response to chemotherapy defined by the validated chemotherapy response score.Results A total of 365 patients were included: 219 (60.0%) received 3–4 cycles of neoadjuvant chemotherapy, and 146 (40.0%) had 6 cycles of neoadjuvant chemotherapy before cytoreductive surgery. There were no significant differences in early relapses, disease-free survival, and overall survival according to the number of neoadjuvant chemotherapy cycles. However, regardless of the number cycles of neoadjuvant chemotherapy, persistent extensive histological disease (chemotherapy response score 1–2) was significantly associated with a higher peritoneal cancer index, minimal residual disease (CC-1), and early relapses. Median disease-free survival in patients with complete or near-complete response (score 3) was 28.3 months (95% CI 21.6 to 36.8), whereas it was 16.3 months in patients with chemotherapy response score 1–2 (95% CI 14.7 to 18.0, p<0.001).Conclusion In our cohort, the number of neoadjuvant chemotherapy cycles was not associated with disease-free survival or overall survival. Chemotherapy response score 3 improved oncological outcome regardless of the number of neoadjuvant chemotherapy cycles.All data relevant to the study are included in the article or uploaded as supplementary information. ER -