PT  - JOURNAL ARTICLE
AU  - Ping Liu
AU  - Yu-Lei Sun
AU  - Jie Du
AU  - Xiao-Sai Hou
AU  - Hua Meng
TI  - CD105/Ki67 Coexpression Correlates With Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer
AID  - 10.1097/IGC.0b013e31823c36b8
DP  - 2012 May 01
TA  - International Journal of Gynecologic Cancer
PG  - 586--592
VI  - 22
IP  - 4
4099  - http://ijgc.bmj.com/content/22/4/586.short
4100  - http://ijgc.bmj.com/content/22/4/586.full
SO  - Int J Gynecol Cancer2012 May 01; 22
AB  - Aim To analyze the expression patterns of CD105 and Ki67 in human epithelial ovarian cancer (EOC) and to evaluate the clinical significance of these two markers in the progression and prognosis in EOC.Materials and Methods The CD105 and Ki67 protein expression patterns in paraffin-embedded specimens gathered from 166 patients with EOC were detected by immunohistochemistry analysis. The association of CD105 and Ki67 protein expression with the prognosis in EOC was subsequently assessed.Results The CD105 and Ki67 proteins were positively expressed in 101/166 (60.8%) and 129/166 (77.7%) of EOC patients, respectively. The CD105+ tumors are more likely to have higher tumor grade (P = 0.02). Patients with positive Ki67 staining are more likely to be at the advanced stage of the disease (P = 0.008). Marker CD105 was positively correlated with Ki67 (r = 0.66, P = 0.01). In addition, Ki67 (hazards ratio [HR], 4.8; confidence interval [CI], 1.2–16.6; P = 0.008) and CD105 (HR, 4.1; CI, 1.0–15.2; P = 0.01) were both independent prognostic factors for poor overall survival in EOC patients. Furthermore, combined CD105/Ki67 expression was significantly related to unfavorable overall survival (HR, 16.6; CI, 1.2–128.9; P < 0.001).Conclusions Our results suggest that the CD105 and Ki67 expressions might be involved in the progression of EOC and patient prognosis. A combined detection of CD105/Ki67 coexpression may benefit us in predicting the prognosis in EOC.