TY - JOUR T1 - Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer: What Is the Best Approach? JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 543 LP - 549 DO - 10.1097/IGC.0000000000000914 VL - 27 IS - 3 AU - Marcelo Vailati Negrão AU - Julianne Maria da Silva Lima AU - Samantha Cabral Severino Silva AU - Maria Del Pilar Estevez Diz AU - Vanessa da Costa Miranda Y1 - 2017/03/01 UR - http://ijgc.bmj.com/content/27/3/543.abstract N2 - Abstract Cervical cancer remains a prevalent and deadly disease in low-income countries, especially among young and otherwise healthy women. Multimodality treatment has led to a significant improvement in outcomes for patients with locally advanced disease, and this is mainly because of the incorporation of platinum-based chemoradiotherapy in current treatment protocols. However, locally advanced tumors are associated with a greater risk for para-aortic lymph node (PALN) involvement, which is an important adverse prognostic factor. Most staging techniques have low accuracy for detection of disease in this area, which could lead to understaging and undertreatment. Meanwhile, patients with PALN disease are underrepresented in trials addressing the treatment of advanced cervical cancer and a few studies have been directed at this population. The aim of this review is to analyze the current data regarding staging and treatment of cervical cancer with PALN disease to determine which strategy is best when managing these patients. ER -