RT Journal Article
SR Electronic
T1 Metabolic profile of patients with endometrial adenocarcinoma and association with tumor grade
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 626
OP 632
DO 10.1136/ijgc-2021-003245
VO 32
IS 5
A1 João Paulo Andrade Fernandes
A1 Alex Oliveira da Camara
A1 Fernando Trevisan Frajacomo
A1 Claudia Bessa Pereira Chaves
A1 Avany Fernandes Pereira
A1 Gabriela Villaça Chaves
YR 2022
UL http://ijgc.bmj.com/content/32/5/626.abstract
AB Objective To describe the prevalence of metabolic syndrome and other metabolic indicators in patients with endometrial cancer and its association with tumor grade.Methods This is a cross-sectional study of patients with endometrial cancer referred to the Brazilian National Cancer Institute. We collected data on sociodemographic variables, smoking, co-morbidities, physical activity level, menopausal status, and tumor characteristics (histological subtype, stage, and tumor grade). In addition, weight, height, and waist circumference were measured. Laboratory evaluation included lipid profile, fasting blood glucose and insulin, and C-reactive protein. Insulin resistance was estimated by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Characterization of metabolic syndrome and cardiovascular risk profile was performed. Binary logistic regression models were used to test the association between metabolic syndrome and its metabolic parameters, HOMA-IR, and C-reactive protein with tumor grade.Results We included a total of 313 patients, 245 (78.3%) aged <65 years, 262 (83.7%) with endometrioid adenocarcinoma, 193 (61.7%) early stage, and 201 (64.2%) with lower tumor grade (G1 and G2). Metabolic syndrome, insulin resistance, and low levels of leisure-time physical activity were highly prevalent (90.7%). In binary logistic regression models, an association was observed between HOMA-IR and lower tumor grade (p<0.05), while high-grade tumors were associated with the highest C-reactive protein values (p<0.05).Conclusion The main finding of this study was the association between insulin resistance and low-grade tumors, and the association between high C-reactive protein levels and high-grade tumors.Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information.