RT Journal Article
SR Electronic
T1 Sociodemographic characteristics and cervical cancer survival in different regions of the United States: a National Cancer Database study
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP ijgc-2021-003227
DO 10.1136/ijgc-2021-003227
A1 Toboni, Michael D
A1 Cohen, Alexander
A1 Gentry, Zachary L
A1 Ostby, Stuart A
A1 Wang, Zhixin
A1 Bae, Sejong
A1 Leath, Charles
YR 2022
UL http://ijgc.bmj.com/content/early/2022/04/14/ijgc-2021-003227.abstract
AB Objective To determine how sociodemographic factors impact cervical cancer survival in different geographic locations in the USA.Methods A retrospective cohort of patients with cervical cancer from January 1, 2004 to December 31, 2015 in the National Cancer Database (NCDB) was identified. Tumor characteristics as well as race, income, insurance type, and treating facility types were compared among nine geographic regions. χ2 tests and Cox regression were used to compare differences between regions; p values <0.05 were considered significant.Results A total of 48 787 patients were included. Survival was inferior in seven of nine regions for underinsured patients. In six regions survival was inferior for Medicaid and Medicare patients, respectively: Middle Atlantic: hazard ratio (HR) 1.25 and 1.22; South Atlantic: HR 1.41 and HR 1.22; East North Central: HR 1.36 and HR 1.25; East South Central: HR 1.37 and HR 1.25; West North Central: HR 1.67 and HR 1.42; West South Central: HR 1.44 and HR 1.46. In the Pacific region survival was inferior for Medicare patients (HR 1.35) but not inferior for Medicaid patients. Being uninsured was associated with worse survival in the South Atlantic (HR 1.23), East North Central (HR 1.23), East South Central (HR 1.56), and West South Central (HR 1.31) regions. Annual income level under $38 000 was associated with worse survival in the Middle Atlantic (HR 1.24), South Atlantic (HR 1.35), and East North Central (HR 1.49) regions. Lastly, when compared with academic research institutions, comprehensive community cancer centers had significantly worse survival in four of the nine regions.Conclusions Cervical cancer mortality is higher for women with a low income, underinsured (Medicaid or Medicare) or uninsured status, and decreased access to academic institutions in most US regions. An increase in cervical cancer mortality was associated with underinsured or uninsured populations in regions mainly located in the South and Midwest.Data may be obtained from a third party and are not publicly available. Data was obtained from the National Cancer Database. In accordance with the journal’s guidelines, public use data are available at https://www.facs.org/quality-programs/cancer/ncdb/puf and SAS analyzed data can be provided for the reproducibility of this study if such is requested.