RT Journal Article
SR Electronic
T1 Diagnostic Implications of p16 Expression in Serous Papillary Endometrial Cancer
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1441
OP 1445
DO 10.1097/IGC.0b013e31822eee04
VO 21
IS 8
A1 Itamar M. Netzer
A1 Hedwiga Kerner
A1 Ludmila Litwin
A1 Lior Lowenstein
A1 Amnon Amit
YR 2011
UL http://ijgc.bmj.com/content/21/8/1441.abstract
AB Objective: The purpose of this study was to examine whether the degree of expression of the p16 protein in serous papillary endometrial cancer bears a prognostic significance. The secondary objective was to establish the value of p16 immunohistochemical staining as an adjunct to diagnosis.Study Design: Archived paraffin blocks holding specimens from the uteri of 31 serous papillary and 31 endometrioid endometrial carcinoma patients were recut and restained for p16 and p53.Results: Overexpression of p16 was found in 78% of the serous papillary patients versus 36% of the endometrioid patients. p16 was not found to be an independent prognostic factor in serous papillary endometrial carcinoma.Conclusions: Although p16 was not found to have prognostic significance in serous papillary endometrial carcinoma, it may be valuable as a diagnostic adjunct in histologically ambiguous tumors.