TY - JOUR T1 - Diagnostic Implications of p16 Expression in Serous Papillary Endometrial Cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1441 LP - 1445 DO - 10.1097/IGC.0b013e31822eee04 VL - 21 IS - 8 AU - Itamar M. Netzer AU - Hedwiga Kerner AU - Ludmila Litwin AU - Lior Lowenstein AU - Amnon Amit Y1 - 2011/11/01 UR - http://ijgc.bmj.com/content/21/8/1441.abstract N2 - Objective: The purpose of this study was to examine whether the degree of expression of the p16 protein in serous papillary endometrial cancer bears a prognostic significance. The secondary objective was to establish the value of p16 immunohistochemical staining as an adjunct to diagnosis.Study Design: Archived paraffin blocks holding specimens from the uteri of 31 serous papillary and 31 endometrioid endometrial carcinoma patients were recut and restained for p16 and p53.Results: Overexpression of p16 was found in 78% of the serous papillary patients versus 36% of the endometrioid patients. p16 was not found to be an independent prognostic factor in serous papillary endometrial carcinoma.Conclusions: Although p16 was not found to have prognostic significance in serous papillary endometrial carcinoma, it may be valuable as a diagnostic adjunct in histologically ambiguous tumors. ER -