PT  - JOURNAL ARTICLE
AU  - Netzer, Itamar M.
AU  - Kerner, Hedwiga
AU  - Litwin, Ludmila
AU  - Lowenstein, Lior
AU  - Amit, Amnon
TI  - Diagnostic Implications of p16 Expression in Serous Papillary Endometrial Cancer
AID  - 10.1097/IGC.0b013e31822eee04
DP  - 2011 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1441--1445
VI  - 21
IP  - 8
4099  - http://ijgc.bmj.com/content/21/8/1441.short
4100  - http://ijgc.bmj.com/content/21/8/1441.full
SO  - Int J Gynecol Cancer2011 Nov 01; 21
AB  - Objective: The purpose of this study was to examine whether the degree of expression of the p16 protein in serous papillary endometrial cancer bears a prognostic significance. The secondary objective was to establish the value of p16 immunohistochemical staining as an adjunct to diagnosis.Study Design: Archived paraffin blocks holding specimens from the uteri of 31 serous papillary and 31 endometrioid endometrial carcinoma patients were recut and restained for p16 and p53.Results: Overexpression of p16 was found in 78% of the serous papillary patients versus 36% of the endometrioid patients. p16 was not found to be an independent prognostic factor in serous papillary endometrial carcinoma.Conclusions: Although p16 was not found to have prognostic significance in serous papillary endometrial carcinoma, it may be valuable as a diagnostic adjunct in histologically ambiguous tumors.