RT Journal Article SR Electronic T1 Radical Vaginal Trachelectomy (RVT) Combined With Laparoscopic Lymphadenectomy: Prospective Study of 225 Patients With Early-Stage Cervical Cancer JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 1458 OP 1464 DO 10.1097/IGC.0b013e3182216aa7 VO 21 IS 8 A1 Lanowska, Malgorzata A1 Mangler, Mandy A1 Spek, Annabel A1 Grittner, Ulrike A1 Hasenbein, Kati A1 Chiantera, Vito A1 Hertel, Hermann A1 Schneider, Achim A1 Köhler, Christhardt A1 Speiser, Dorothee YR 2011 UL http://ijgc.bmj.com/content/21/8/1458.abstract AB Objective: The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood.Methods: A database of 225 patients with early-stage cervical cancer and intention to treat by RVT after laparoscopic lymphadenectomy was prospectively maintained. A total of 212 patients were treated according to the protocol. The procedure was preformed in a standardized manner, and life table analysis was applied.Results: In the cohort of patients treated according to protocol, 8 recurrences occurred and 4 patients died from recurrence. The median follow-up time was 37 months (range, 0-171 months). The 5-year recurrence-free and overall survival was 94.4% and 97.4%, respectively. Perioperative and short-term postoperative complications were rare (2.8% and 7.5%, respectively). No severe long-term complications occurred.Conclusions: Radical vaginal trachelectomy combined with laparoscopic lymphadenectomy is a safe method for treatment of patients with early-stage cervical cancer who are seeking parenthood.