RT Journal Article
SR Electronic
T1 The Combination of Preoperative Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Sentinel Lymph Node Mapping in the Surgical Management of Endometrioid Endometrial Cancer
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1228
OP 1238
DO 10.1097/IGC.0000000000000773
VO 26
IS 7
A1 Tugan Bese
A1 Veysel Sal
A1 Fuat Demirkiran
A1 Ilker Kahramanoglu
A1 Nedim Tokgozoglu
A1 Sennur Ilvan
A1 Ovgu Aydin
A1 Metin Hallac
A1 Betul Vatankulu
A1 Gokhan Demirayak
A1 Hasan Turan
A1 Macit Arvas
YR 2016
UL http://ijgc.bmj.com/content/26/7/1228.abstract
AB Objective The goal of this study was to evaluate the combination of sentinel lymph node (SLN) mapping and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan in detection of lymph node involvement in patients with endometrioid endometrial cancer (EEC).Methods/Materials Ninety-five patients with EEC who had preoperative PET/CT imaging and underwent SLN mapping were retrospectively analyzed. Methylene blue dye was used and injected to the cervix at 3- and 9-o’clock positions (a total of 4 mL). Pelvic lymphadenectomy was performed on all of the patients after SLN mapping. If the SLN was negative in the initial hematoxylin and eosin staining, an ultrastaging study was performed for the SLNs.Results Sentinel lymph nodes were detected in 77 (81.1%) of 95 patients, with a mean of 2.951–9 SLNs. There was only 1 case (1.4%) with a positive SLN in the intraoperative frozen section examination in those patients with negative PET/CT findings and in whom SLNs were detected (n = 70). Among the remaining 69 patients with negative preoperative PET/CT findings and negative frozen section results for the SLNs, there were 2 patients with SLN involvement in the final ultrastaging pathology. In the patient-based analyses, the sensitivity, specificity, and positive and negative predictive values of the PET/CT and SLN frozen section were 33%, 100%, 100%, and 97.1%, respectively.Conclusions As no metastases in the nonsentinel pelvic lymph nodes were found in patients with EEC who had both negative PET/CT findings and frozen section results of the SLNs in both hemipelvises, we suggest using both methods to reduce the incidence of unnecessary systematic lymphadenectomy.