RT Journal Article
SR Electronic
T1 Clinical impact of SARS-CoV-2 infection among patients with vulvar cancer: the Gemelli Vul.Can multidisciplinary team
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 127
OP 132
DO 10.1136/ijgc-2021-003026
VO 32
IS 2
A1 Alex Federico
A1 Simona Maria Fragomeni
A1 Luca Tagliaferri
A1 Linda Stella Guajardo Rios
A1 Valentina Lancellotta
A1 Stefano Gentileschi
A1 Giacomo Corrado
A1 Benedetta Gui
A1 Giuseppe Colloca
A1 Vittoria Rufini
A1 Anna Fagotti
A1 Giovanni Scambia
A1 Giorgia Garganese
YR 2022
UL http://ijgc.bmj.com/content/32/2/127.abstract
AB Background ‘Severe acute respiratory syndrome coronavirus-2’ (SARS-CoV-2) infection has dramatically affected the management of patients with cancer, who are most vulnerable to the consequences of the infection. Patients with vulvar cancer are frequently elderly and affected by multiple co-morbidities, thus representing a particularly frail population.Objective To assess the clinical impact of the SARS-CoV-2 infection among patients scheduled for treatment for active vulvar cancer.Methods Data on patients with vulvar tumors referred to Fondazione Policlinico Universitario Agostino Gemelli IRCCS between February 2020 and July 2021 were retrospectively analyzed. Patients with a positive reverse transcription polymerase chain reaction in nasopharyngeal swab were considered as positive for SARS-Cov-2.Results One hundred and ninety-one patients with vulvar cancer were evaluated and scheduled for treatment. The median age was 72 years (range 35–94). Seven (3.7%) patients were diagnosed with SARS-Cov-2 infection: three (42.9%) had their treatment delayed, with no apparent consequences, two (28.6%) had their treatment delayed and later abandoned because of clinical worsening due to oncologic disease progression, and two (28.6%) contracted the infection in the post-operative period and died due to respiratory complications.Conclusions In most cases the infection had major clinical implications, being associated with significant delays in oncologic treatments and extremely high mortality when contracted in the post-operative period.All data relevant to the study are included in the article or uploaded as supplementary information. Not applicable.