@article {ReidA109, author = {R Reid and Y Xie and J Shi and K Wallace}, title = {EPV201/$\#$44 Real-world data analysis of second-line poly (ADP-RIBOSE) polymerase inhibitor maintenance therapy in patients with advanced ovarian cancer}, volume = {31}, number = {Suppl 4}, pages = {A109--A109}, year = {2021}, doi = {10.1136/ijgc-2021-IGCS.272}, publisher = {BMJ Specialist Journals}, abstract = {Objectives Poly(ADP-ribose) polymerase inhibitors (PARPis) have been recommended since 2017 as second-line (2L) maintenance treatment by the NCCN for ovarian cancer (OC) patients with or without BRCA1 or BRCA2 (BRCA) alterations. Here, we assessed PARPi use from real-world data.Methods From the iKnowMed electronic health record database of the US Oncology Network (\>470 sites), adult females were included if they were diagnosed with advanced OC, received a 2L platinum-containing regimen for advanced OC, and had >=2 visits between 1 January 2016 and 1 July 2020. Patients were followed until 31 October 2020, last patient record, or death, whichever occurred earliest. A 24-month landmark survival analysis was performed.Results Out of 11,494 patients diagnosed with advanced OC, 1051 met the inclusion criteria; 513/1051 (49\%) subsequently received any maintenance therapy (table 1). The proportion of patients receiving 2L PARPi maintenance increased from 17\% in 2018 to 34\% in 2019 but decreased to 22\% in 2020 (figure 1). Among BRCA+patients, 33\% (46/140) received 2L PARPi maintenance, while documented BRCA{\textendash}patients received PARPi maintenance at a significantly lower rate (23\%; 155/622; P=0.0192). Survival at 24 months was significantly higher with PARPi maintenance vs active surveillance: 61.2\% (95\% CI, 52.4\%{\textendash}68.8\%) vs 53.0\% (95\% CI, 47.1\%{\textendash}58.7\%; log-rank P=0.0045) (figure 2).View this table:Abstract EPV201/$\#$44 Table 1 Abstract EPV201/$\#$44 Figure 1 Propotion of patients receiving 2L PARPi maintenance (active surveillance)Abstract EPV201/$\#$44 Figure 2 Overall survivalConclusions Our data suggest a significant proportion of eligible patients are not receiving 2L maintenance therapy despite treatment guideline recommendations and apparent survival benefits associated with its use.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/31/Suppl_4/A109.1}, eprint = {https://ijgc.bmj.com/content/31/Suppl_4/A109.1.full.pdf}, journal = {International Journal of Gynecologic Cancer} }