PT - JOURNAL ARTICLE AU - V Gupta AU - S Salvador AU - W Gotlieb AU - S Lau TI - SF013/#236 Robotic approach for a total hysterectomy bilateral salpingo-oophorectomy and suction curettage of a 20-week size uterus with gestational trophoblastic neoplasia AID - 10.1136/ijgc-2021-IGCS.57 DP - 2021 Nov 01 TA - International Journal of Gynecologic Cancer PG - A26--A26 VI - 31 IP - Suppl 4 4099 - http://ijgc.bmj.com/content/31/Suppl_4/A26.2.short 4100 - http://ijgc.bmj.com/content/31/Suppl_4/A26.2.full SO - Int J Gynecol Cancer2021 Nov 01; 31 AB - Introduction Gestational trophoblastic neoplasia (GTN) is a malignant trophoblastic disease following either molar or non-molar pregnancies. GTN is primarily treated through uterine evacuation using suction curettage followed by observation or adjuvant chemotherapy based on WHO risk scoring.1,2 In patients who have completed child-bearing, hysterectomy is an acceptable option and may decrease time to remission and required chemotherapy cycles.2 In patients presenting with large volume uterine disease, evidence of metastasis, and high-risk WHO scoring, patients are treated with multi-agent chemotherapy including Etopisode, Methotrexate, Actinomycin-D, Cycophosphamide, and Vincristine (EMA-CA).1,2 EMA-CO has significant risks of complications, including acute hemorrhage and trophoblastic emboli.2,3 In patients with large uteri, surgical risks include uterine perforation and acute hemorrhage,4 requiring a large laparotomic incision. Accordingly, there is a need for risk-reducing minimally invasive approaches in the surgical treatment of GTN.Description The patient is a 53 year old G4P4 presenting with an enlarged uterus of 20 cm with snowstorm appearance, a beta-hCG >400 000IU, lung metastases and a WHO risk score of 8. Preoperatively her blood pressure was 168/105. She underwent a robotic total hysterectomy and bilateral salpingo-oophorectomy, and guided suction curettage. Blood loss was minimal. The patient was scored post-procedure as WHO low risk (3). She received methotrexate, and switched to Actinomycin-D after a plateau in beta-hCG. Her beta-hCG is normal 5 months later.Conclusion We present a minimally invasive approach that ameliorates the surgical and chemotherapy risks of uterine rupture, acute hemorrhage, and trophoblastic emboli, with a normalization of beta-hCGs after treatment with single-agent chemotherapy.