RT Journal Article SR Electronic T1 EPV043/#200 The increasing incidence of metastatic cervical cancer in the United States – what factors are responsible? JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP A46 OP A46 DO 10.1136/ijgc-2021-IGCS.111 VO 31 IS Suppl 4 A1 C-I Liao A1 A Francoeur A1 A Milki A1 E Thayer A1 A Mann A1 MA Caesar A1 A Chan A1 B Monk A1 D Kapp A1 J Chan YR 2021 UL http://ijgc.bmj.com/content/31/Suppl_4/A46.2.abstract AB Objectives To determine the incidence and trends of advanced stage cervical cancer in the United States.Methods Data were obtained from the U.S. Cancer Statistics program from 2001–2017. SEER*Stat 8.3.8 and Joinpoint regression program 4.8.0.1 were used to calculate incidence trends.Results of 27,102 patients with advanced stage cervical cancer from 2001–2017, 17,097 (63%) were White, 4,939 (5%) were Black, 3,636 were Hispanic (2%), and 1,117 were Asian (0.5%). Over time, there has been an annual increase in advanced stage cervical cancer at a rate of nearly 2% per year (p<0.001); however, those with early stage cancers have a decrease of 1.54% annually (p<0.001). Women aged 30 to 65 years showed an overall increase in incidence, however those 30–34 years olds have a particularly high increase at 3.39% annually (p<0.001). Although the overall incidence of advanced cancers is higher in Hispanic and Black populations, there is an increasing number of new cases in White women at 2.39% annually (p<0.001). Compared to other groups, the intersection of White women aged 40–44 in the South have the highest average annual increase at 5.07% (p<0.001).Conclusions Although the overall incidence of advanced cervical cancers is highest in Hispanic and Black women, there is an increase in incidence in White women particularly in the Southern region of the U.S. More research is needed to understand this trend particularly in relation to screening and treatment of precancerous disease.