RT Journal Article
SR Electronic
T1 EPV115/#333 Interim analysis of 10-year data regarding presentation and management of uterine carcinosarcoma (UCS) cases across the thames valley cancer alliance network
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A75
OP A76
DO 10.1136/ijgc-2021-IGCS.185
VO 31
IS Suppl 4
A1 Gkorila, A
A1 Smyth, S
A1 Tupper, P
A1 Mcculloch, A
A1 Sadeghi, N
A1 Le Thanh, V
A1 Sattar, A
A1 Spencer, S
A1 Zarrindej, K
A1 Abdalla, M
A1 Addley, S
A1 Rencher, J
A1 Sharma, G
A1 Kashif, A
A1 Siddiki, S
A1 Alazzam, M
A1 Soleymani Majd, H
YR 2021
UL http://ijgc.bmj.com/content/31/Suppl_4/A75.3.abstract
AB Objectives UCS comprises <5% of uterine malignancies, accounting for >15% associated mortality. With no established guidelines, we present our experience to determine clinical characteristics, treatment modalities and histology outcomes of UCS.Methods We conducted a multicentre retrospective cohort study, including all surgically managed UCS cases between March 2010 and January 2020. Data was collected on patients’ demographics, medical history, pre-operative and final histology and FIGO staging, peri-operative and post-operative findings.Results 82 (9.7%) UCS cases were identified from a total of 847 surgically managed uterine cancers, with 51 diagnosed with UCS. 3 cases were down and 12 up-staged following surgery. 15 cases of MRI lymphadenopathy led to a PPV of 40%. Positive lymph nodes and omentum were identified in 15.8% and 11.3% of cases respectively, with half of lymph node metastases diagnosed following systematic dissection (the majority of which were LVSI positive). There were no operative complication themes.View this table:Abstract EPV115/#333 Table 1 Pre-operative characteristics and ivestigations of patients with UCSView this table:Abstract EPV115/#333 Table 2 Treatment modalities and outcomes of patients with UCSConclusions UCS presented with almost double the incidence rate previously described. The overall accuracy of pre-operative staging was 81%. Our analysis showed that 86% of cases were managed laparoscopically, with more favourable peri-operative and post-operative profiles. Despite the lack of management guidelines, we stress the importance of urgent surgical treatment for UCS, in the form of total hysterectomy, bilateral salpingo-oophorectomy, systematic bilateral pelvic lymph node dissection and omentectomy. Data on adjuvant treatment, recurrence and survival is currently under analysis.