PT  - JOURNAL ARTICLE
AU  - A Rosati
AU  - S Cianci
AU  - V Vargiu
AU  - VA Capozzi
AU  - G Sozzi
AU  - R Berretta
AU  - F Cosentino
AU  - S Gueli Alletti
AU  - A Ercoli
AU  - V Chiantera
AU  - G Scambia
AU  - F Fanfani
TI  - EPV138/#609 Sentinel lymph-node in aged endometrial cancer patients ‘the sage study’: a multicenter experience
AID  - 10.1136/ijgc-2021-IGCS.208
DP  - 2021 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - A85--A85
VI  - 31
IP  - Suppl 4
4099  - http://ijgc.bmj.com/content/31/Suppl_4/A85.1.short
4100  - http://ijgc.bmj.com/content/31/Suppl_4/A85.1.full
SO  - Int J Gynecol Cancer2021 Nov 01; 31
AB  - Objectives The prevalence of Endometrial Cancer (EC) progressively increases with age, therefore, with the general aging of the population, we will have to treat a rising number of patients defined as ‘elderly’. The main study goal was to assess the overall detection rate, the bilateral mapping, and the mapping failure rate in elderly patients, and to evaluate SLN anatomical distribution and predictors for mapping failure.Methods A cohort of patients with apparently early-stage EC undergoing SLN biopsy between May-2015 and March-2021, in 4 Italian referral Cancer-Center, were retrospectively retrieved. The study population has been divided into women under and over 65 (Group-1 and 2).Results Eight-hundred-forty-four women were enrolled (group 1: 449, group 2: 395). A 1.280-fold increase in the risk of failed mapping per 10-year-old increase (OR: 1.280, p=0.001) and a decrease of both overall detection rate and bilateral mapping were found (respectively OR: 0.726, p=0.006 and OR 0.781, p=0.001) (figure 1). A decreased SLN mapping along the ‘uncommon sites’ was noted in older women (left hemiplevis: 15.7% vs 7, 1%, p <0.001; right hemiplevis 13.2% vs 8.6%, p =0.058) (figure 2).Abstract EPV138/#609 Figure 1 Bionominal logistic regression analysis for 10 year age increaseUnivariate analysis per 10 year age increaseMapping failure risk: OR: 1.280 (95% CI: 1.108-1.479, p=0.001)Overall detection rate: OR 0.726 (95% CI: 0.577-0.913, p=0.006)Successful maping rate: OR 0.781 (95% CI: 0.676-0.902, p=0.001)Abstract EPV138/#609 Figure 2 Anatomical localizations of sentinel lymph nodesConclusions Age represented an independent predictor of unsuccessful mapping and affects the anatomical distribution of the SLN leading to a stepwise reduction of ‘uncommon’ mapping sites.