RT Journal Article
SR Electronic
T1 De novo uterine sarcoma with good response to neo-adjuvant chemotherapy
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 364
OP 367
DO 10.1136/ijgc-00009577-200305000-00017
VO 13
IS 3
A1 F. NUMA
A1 K. UMAYAHARA
A1 H. OGATA
A1 S. NAWATA
A1 Y. SAKAGUCHI
A1 T. EMOTO
A1 K. KAWASAKI
A1 H. HIRAKAWA
A1 M. SASE
A1 A. OGA
A1 H. KATO
YR 2003
UL http://ijgc.bmj.com/content/13/3/364.abstract
AB We report here the extremely rare case of a 28-year-old woman with advanced stage uterine sarcoma arising soon after a cesarean section. She underwent an abdominal cesarean section because of a breech presentation. At the time of the procedure, there were no abnormal findings such as leiomyoma of the uterus in the abdominal cavity. One year later, she was referred to our hospital because of a large abdominal tumor. Transabdominal power Doppler ultrasonography and magnetic resonance imaging (MRI) showed a large hypervascular tumor in the abdominal cavity. Her serum levels, for the two tumor markers carbohydrate antigen CA125 and LDH, were elevated, at 219 U/ml (< 35 U/ml) and 862 IU/l (115 U/ml−217 U/ml), respectively. On the basis of a diagnosis of malignant tumor of gynecological origin, exploratory laparotomy was performed, and through biopsy, the tumor was found to be advanced undifferentiated uterine sarcoma. She exhibited a good response to neoadjuvant chemotherapy consisting of cisplatin, epirubicin, and dimethyltriazenoimidazole carboxamide (DTIC) every 28 days, which was successfully followed by a hysterectomy.