RT Journal Article
SR Electronic
T1 Implications of human papillomavirus type for survival in cervical squamous cell carcinoma
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 341
OP 345
DO 10.1046/j.1525-1438.1995.05050341.x
VO 5
IS 5
A1 B. HAGMAR
A1 J.-J. P. CHRISTENSEN
A1 B. JOHANSSON
A1 M. KALANTARI
A1 W. RYD
A1 B. SKYLDBERG
A1 L. WALAAS
A1 B. WÄRLEBY
A1 G. B. KRISTENSEN
YR 1995
UL http://ijgc.bmj.com/content/5/5/341.abstract
AB In a Swedish series of 107 invasive squamous carcinomas of the cervix, DNA extraction from paraffin-embedded material was successful in 97 cases. The prevalence of human papillomavirus (HPV) in this material was 86.6%, as determined by polymerase chain reaction (PCR) using both consensus and type-specific primers. HPV type 16 was most common (42.3%; other types were 31 (12.3%), 18 (9.3%) and 33 (10.3%). Seventeen cases (17.3%) were positive for the consensus primers only and were regarded as HPV of unknown type. There was no significant difference in corrected survival between patients with HPV-positive or -negative tumors. In the HPV-positive group, patients with tumors containing HPV 33 or HPV 18 had a significantly poorer prognosis than patients with tumors containing other types of HPV DNA (relative hazard 3.18, 95% confidence interval 1.37–7.39, P = 0.007), implying a prognostic significance of HPV type.