PT - JOURNAL ARTICLE AU - B. HAGMAR AU - J.-J. P. CHRISTENSEN AU - B. JOHANSSON AU - M. KALANTARI AU - W. RYD AU - B. SKYLDBERG AU - L. WALAAS AU - B. WÄRLEBY AU - G. B. KRISTENSEN TI - Implications of human papillomavirus type for survival in cervical squamous cell carcinoma AID - 10.1046/j.1525-1438.1995.05050341.x DP - 1995 Sep 01 TA - International Journal of Gynecologic Cancer PG - 341--345 VI - 5 IP - 5 4099 - http://ijgc.bmj.com/content/5/5/341.short 4100 - http://ijgc.bmj.com/content/5/5/341.full SO - Int J Gynecol Cancer1995 Sep 01; 5 AB - In a Swedish series of 107 invasive squamous carcinomas of the cervix, DNA extraction from paraffin-embedded material was successful in 97 cases. The prevalence of human papillomavirus (HPV) in this material was 86.6%, as determined by polymerase chain reaction (PCR) using both consensus and type-specific primers. HPV type 16 was most common (42.3%; other types were 31 (12.3%), 18 (9.3%) and 33 (10.3%). Seventeen cases (17.3%) were positive for the consensus primers only and were regarded as HPV of unknown type. There was no significant difference in corrected survival between patients with HPV-positive or -negative tumors. In the HPV-positive group, patients with tumors containing HPV 33 or HPV 18 had a significantly poorer prognosis than patients with tumors containing other types of HPV DNA (relative hazard 3.18, 95% confidence interval 1.37–7.39, P = 0.007), implying a prognostic significance of HPV type.