TY - JOUR T1 - Implications of human papillomavirus type for survival in cervical squamous cell carcinoma JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 341 LP - 345 DO - 10.1046/j.1525-1438.1995.05050341.x VL - 5 IS - 5 AU - B. HAGMAR AU - J.-J. P. CHRISTENSEN AU - B. JOHANSSON AU - M. KALANTARI AU - W. RYD AU - B. SKYLDBERG AU - L. WALAAS AU - B. WÄRLEBY AU - G. B. KRISTENSEN Y1 - 1995/09/01 UR - http://ijgc.bmj.com/content/5/5/341.abstract N2 - In a Swedish series of 107 invasive squamous carcinomas of the cervix, DNA extraction from paraffin-embedded material was successful in 97 cases. The prevalence of human papillomavirus (HPV) in this material was 86.6%, as determined by polymerase chain reaction (PCR) using both consensus and type-specific primers. HPV type 16 was most common (42.3%; other types were 31 (12.3%), 18 (9.3%) and 33 (10.3%). Seventeen cases (17.3%) were positive for the consensus primers only and were regarded as HPV of unknown type. There was no significant difference in corrected survival between patients with HPV-positive or -negative tumors. In the HPV-positive group, patients with tumors containing HPV 33 or HPV 18 had a significantly poorer prognosis than patients with tumors containing other types of HPV DNA (relative hazard 3.18, 95% confidence interval 1.37–7.39, P = 0.007), implying a prognostic significance of HPV type. ER -