PT  - JOURNAL ARTICLE
AU  - J. P.A. BAAK
AU  - W. P. SNIJDERS
AU  - P. J. VAN DIEST
AU  - E. ARMEE-HORVÁTH
AU  - P. KENEMANS
TI  - Confirmation of the prognostic value of the ECPI-1 score (myometrial invasion, DNA-ploidy and mean shortest nuclear axis) in FIGO stage I endometrial cancer patients with long follow-up
AID  - 10.1046/j.1525-1438.1995.05020112.x
DP  - 1995 Mar 01
TA  - International Journal of Gynecologic Cancer
PG  - 112--116
VI  - 5
IP  - 2
4099  - http://ijgc.bmj.com/content/5/2/112.short
4100  - http://ijgc.bmj.com/content/5/2/112.full
SO  - Int J Gynecol Cancer1995 Mar 01; 5
AB  - In FIGO stage I endometrial cancer patients, histologic type and grade are correlated with prognosis and used for therapeutic decision making. However, assessment of these histologic features is subjective, and the results are not always perfectly reproducible. Contrarily, previous studies have shown that DNA-ploidy and morphometric features are highly reproducible and have a strong prognostic value in these cancers. Multivariate analysis has demonstrated that a combination of mean shortest nuclear axis (MSNA), DNA-ploidy and depth of myometrial invasion (the so-called ECPI-1 score) overshadowed the value of all other features investigated. The present study was set up to evaluate further and compare the prognostic power of the ECPI-1 score in 77 FIGO I patients with long follow-up (10–15 years). Grade (revised), invasion depth, MSNA and ploidy were all highly significant. However, the ECPI-1 score (with exactly the same threshold as in the previous study, 0.87) greatly exceeded the prognostic value of these single features. Only two (3%) of the 64 patients with ECPI-1 ⩽0.87 died (at 14 and 62 months), in contrast to 11 (84.6%) of the 13 cases with ECPI-1> 0.87 (10 died within 42 months) (P < 0.0001, Mantel-Cox value = 51.1). These results confirm the prognostic strength of the ECPI-1 score in stage I endometrial carcinoma.