TY - JOUR T1 - Correlation of drug resistance-associated parameters in ovarian tumor biopsies JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 241 LP - 249 DO - 10.1046/j.1525-1438.1994.04040241.x VL - 4 IS - 4 AU - A. T. MCGOWN AU - D. MURPHY AU - R. SWINDELL AU - D. CROWTHER AU - B. W. FOX Y1 - 1994/07/01 UR - http://ijgc.bmj.com/content/4/4/241.abstract N2 - This work compares glutathione levels, glutathione S-transferase activities and isoenzyme expression, metallothionein levels and P-glycoprotein expression in normal ovaries, and in epithelial ovarian tumor biopsies from patients prior to chemotherapy or following relapse. These parameters have been implicated as determinants of response to cytotoxic chemotherapy. Large differences were found between normal ovary and ovarian tumors, but no significant differences were observed between tumors taken before or after cytotoxic chemotherapy. These data do not support a role for these biochemical parameters in the decreased response seen in patients with recurrent or progressive disease. ER -