RT Journal Article
SR Electronic
T1 1064 Role of CA 125, HE4 and IOTA simple rules in differentiating benign and malignant ovarian tumour
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A294
OP A294
DO 10.1136/ijgc-2021-ESGO.512
VO 31
IS Suppl 3
A1 A Bahadur
A1 R Mundhra
A1 N Bhattacharya
YR 2021
UL http://ijgc.bmj.com/content/31/Suppl_3/A294.2.abstract
AB Introduction/Background*This study aimed to evaluate the diagnostic added-value of serum CA-125 & HE4 to the International Ovarian Tumor Analysis (IOTA) Simple Rules for differentiating malignant and benign ovarian tumors preoperatively.Methodology A Cross sectional study was conducted in the Department of Obstetrics and Gynecology on 100 patients with ovarian masses. Demographic and clinical data were prospectively collected. Histopathologic diagnosis was used as the gold standard test. Evaluation of the utility of HE4, CA125 and IOTs simple rules for preoperative identification of malignacy was based on the increment of the area under the receiver operating characteristic curve (AuROC).Result(s)*Out of the 50 suspected benign masses as per IOTA simple rules, post surgery (considering histopathology as gold standard) 32 (64%) were diagnosed as benign ovarian masses, 4 (8%) borderline and 14 (28%) other malignant ovarian tumors on final histopathology. Out of 50 suspected malignant masses as per IOTA simple rules, 26 (52%) were finally diagnosed as benign, 4(8%) borderline and 20 (40%) were malignant. Sensitivity of combined testing of both tumour markers (HE4 and Ca-125) and IOTA together was calculated to be a 85.3% (69-95) whereas its specificity increased to be 94.8% (86-99). Positive predictive value was determined to 90.6% (75-98) and negative predictive value was calculated 91.7% (82-97) making its diagnostic accuracy as 91.3% (84-96).Conclusion*Combining IOTA Simple rules with knpown tumour markers (CA125 and HE4) increases diagnostic accuracy in predicting malignat ovarian masses preoperatively