RT Journal Article
SR Electronic
T1 Staging Lymphadenectomy in Patients With Clear Cell Carcinoma of the Ovary
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 120
OP 124
DO 10.1097/IGC.0000000000000559
VO 26
IS 1
A1 Jennifer J. Mueller
A1 Marie Holzapfel
A1 Chan H. Han
A1 Kevin Santos
A1 Camille Gunderson
A1 Kathleen Moore
A1 Britt Erickson
A1 Charles A. Leath
A1 Elena Diaz
A1 Christine Walsh
A1 Stephanie L. Wethington
A1 Sheila Z. Dejbakhsh
A1 Richard R. Barakat
A1 Ginger J. Gardner
A1 David M. Hyman
A1 Robert A. Soslow
A1 Mario M. Leitao
YR 2016
UL http://ijgc.bmj.com/content/26/1/120.abstract
AB Objective The purpose of this study was to assess the rate of lymph node (LN) metastasis in comprehensively staged ovarian clear cell carcinoma (OCCC) clinically confined to the ovary and determine factors associated with LN metastasis.Methods We identified all cases of OCCC treated at 4 institutions from January 1994 through December 2011. We included cases with disease grossly confined to the ovary that had surgical staging performed, including at least 10 LNs sampled. Clinical and pathologic data were abstracted from electronic medical records, and a deidentified data set was compiled and processed at a single institution. Factors potentially associated with LN metastasis were tested. Appropriate statistical tests were performed.Results We identified 145 eligible cases that met the criteria for this analysis. Median age was 52.9 years (range, 30–81 years), and median total LN count was 19 (range, 10–74). Seven (4.8%) of 145 comprehensively staged cases had LN metastasis; 6 of these cases (4.1%) were isolated metastasis. Cytologic washings, peritoneal, omental, and fallopian tube involvement were not associated with nodal metastasis. Cases with ovarian surface involvement and positive cytology had a 37.5% incidence of LN positivity, which was statistically meaningful when compared with all other cases (P = 0.003).Conclusions Women who underwent comprehensive staging for clinical stage I OCCC had an LN metastasis rate of 4.8%. The subgroup of cases with both ovarian surface involvement and positive cytology had the highest incidence of LN metastasis. This may influence clinical decision making on whether to perform lymphadenectomy in patients with incidental OCCC found after salpingo-oophorectomy.