PT  - JOURNAL ARTICLE
AU  - Greggi, S
AU  - Catalano, O
AU  - Setola, SV
AU  - Casella, G
AU  - Laurelli, G
AU  - Scala, F
AU  - Simeon, V
AU  - Granata, C
AU  - Petrillo, A
AU  - Scaffa, C
TI  - 122 Preoperative imaging assessment of Peritoneal Cancer Index (PCI): concordance with surgical findings in advanced ovarian cancer. A prospective study
AID  - 10.1136/ijgc-2021-ESGO.341
DP  - 2021 Oct 01
TA  - International Journal of Gynecologic Cancer
PG  - A199--A200
VI  - 31
IP  - Suppl 3
4099  - http://ijgc.bmj.com/content/31/Suppl_3/A199.2.short
4100  - http://ijgc.bmj.com/content/31/Suppl_3/A199.2.full
SO  - Int J Gynecol Cancer2021 Oct 01; 31
AB  - Introduction/Background*The extent of peritoneal spread in advanced ovarian cancer (AOC) heavily impacts on the chance of a complete surgical cytoreduction. The decision-making process on the feasibility of cytoreductive surgery should include a dedicated imaging evaluation. The aim of this study was to prospectively compare a radiologic Peritoneal Cancer Index (rPCI) with the surgical PCI (sPCI).Methodology 128 consecutive AOC patients planned for cytoreductive surgery underwent preoperative contrast-enhanced Computed Tomography (CT) scan to calculate the rPCI, then the sPCI was determined intraoperatively. CT scans were performed by two dedicated radiologists, and re-evaluated by a third. The rPCI correlation with sPCI was calculated by Lin’s Concordance Correlation Coefficient (CCC), and represented by Bland-Altman agreement plot and Passing-Bablok regression line.Result(s)*Primary debulking surgery (PDS), and interval debulking surgery (IDS) were performed in 88 and 40 patients, respectively (complete cytoreduction in 56.8% PDS and 67.5% IDS). Overall, mean±SD rPCI was 16.2±6.4 (95%CI:15.1-17.3) and sPCI 14.7±6.9 (95%CI:13.5-15.9), showing a moderate correlation between preoperative CT scan and surgical findings (figures 1-2, CCC=0.64). The best concordance was reported for PDS vs. IDS (CCC=0.64 vs. 0.60) and in middle-high abdominal vs. low quadrants (CCC=0.57 vs. 0.40), while rPCI overestimated ileo-jejunal spread (CCC=0.21).Abstract 122 Figure 1 Abstract 122 Figure 2 Conclusion*CT is moderately accurate in predicting the sPCI in AOC patients. The rPCI scoring seems to be helpful and should be part of the decision-making process on surgical cytoreduction.