RT Journal Article
SR Electronic
T1 Central Nervous System Metastases From Epithelial Ovarian Cancer: Prognostic Factors and Outcomes
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 816
OP 821
DO 10.1097/IGC.0b013e318216cad0
VO 21
IS 5
A1 Gennaro Cormio
A1 Vera Loizzi
A1 Maddalena Falagario
A1 Antonio Calace
A1 Antonio Colamaria
A1 Antonio De Tommasi
A1 Luigi E. Selvaggi
YR 2011
UL http://ijgc.bmj.com/content/21/5/816.abstract
AB Objectives: To analyze the clinicopathological characteristics and prognostic factors associated with survival in patients with central nervous system (CNS) metastases from epithelial ovarian cancer.Methods: Twenty patients with CNS involvement from ovarian carcinoma were evaluated in this retrospective study; their features and survivals were analyzed using Kaplan-Meier and log-rank test methods.Results: The incidence of CNS metastases was 5%, among 400 patients with ovarian cancer treated in our single institution. The median age at diagnosis of the ovarian cancer was 55 years. The median interval to the brain involvement and the median survival were 33 and 18 months, respectively. Prognostic factors associated with survival were the International Federation of Gynecology and Obstetrics stage, the surgical resection, the multimodal treatment, and the response after the therapy of the brain metastases.Conclusions: Brain involvement from ovarian cancer is uncommon but is increasing in incidence. Although the prognosis is usually poor, a multimodal approach can result in a long-term remission of the metastases and in an improvement of the overall survival.