RT Journal Article
SR Electronic
T1 <em>CYP1A1</em> and <em>CYP2D6</em> Gene Polymorphisms in Israeli Jewish Women With Cervical Cancer
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1300-1302
OP 1300-1302
DO 10.1111/IGC.0b013e3181b9fa5d
VO 19
IS 8
A1 Guy Gutman
A1 Tova Morad
A1 Ben Peleg
A1 Chavah Peretz
A1 Amiram Bar-Am
A1 Tamar Safra
A1 Dan Grisaru
YR 2009
UL http://ijgc.bmj.com/content/19/8/1300-1302.abstract
AB Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.