PT  - JOURNAL ARTICLE
AU  - Gutman, Guy
AU  - Morad, Tova
AU  - Peleg, Ben
AU  - Peretz, Chavah
AU  - Bar-Am, Amiram
AU  - Safra, Tamar
AU  - Grisaru, Dan
TI  - <em>CYP1A1</em> and <em>CYP2D6</em> Gene Polymorphisms in Israeli Jewish Women With Cervical Cancer
AID  - 10.1111/IGC.0b013e3181b9fa5d
DP  - 2009 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1300-1302--1300-1302
VI  - 19
IP  - 8
4099  - http://ijgc.bmj.com/content/19/8/1300-1302.short
4100  - http://ijgc.bmj.com/content/19/8/1300-1302.full
SO  - Int J Gynecol Cancer2009 Nov 01; 19
AB  - Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.