TY - JOUR T1 - <em>CYP1A1</em> and <em>CYP2D6</em> Gene Polymorphisms in Israeli Jewish Women With Cervical Cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 1300-1302 LP - 1300-1302 DO - 10.1111/IGC.0b013e3181b9fa5d VL - 19 IS - 8 AU - Guy Gutman AU - Tova Morad AU - Ben Peleg AU - Chavah Peretz AU - Amiram Bar-Am AU - Tamar Safra AU - Dan Grisaru Y1 - 2009/11/01 UR - http://ijgc.bmj.com/content/19/8/1300-1302.abstract N2 - Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population. ER -