RT Journal Article
SR Electronic
T1 Radical hysterectomy in early cervical cancer in Europe: characteristics, outcomes and evaluation of ESGO quality indicators
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP ijgc-2021-002587
DO 10.1136/ijgc-2021-002587
A1 Felix Boria
A1 Luis Chiva
A1 Vanna Zanagnolo
A1 Denis Querleu
A1 Nerea Martin-Calvo
A1 Mihai Emil Căpîlna
A1 Anna Fagotti
A1 Ali Kucukmetin
A1 Constantijne Mom
A1 Galina Chakalova,
A1 Aliyev Shamistan
A1 Mario Malzoni
A1 Fabrice Narducci
A1 Octavio Arencibia
A1 Francesco Raspagliesi
A1 Tayfun Toptas
A1 David Cibula
A1 Dilyara Kaidarova
A1 Mehmet Mutlu Meydanli
A1 Mariana Tavares
A1 Dmytro Golub
A1 Anna Myriam Perrone
A1 Robert Poka
A1 Dimitrios Tsolakidis
A1 Goran Vujić
A1 Marcin A Jedryka
A1 Petra L M Zusterzeel
A1 Jogchum Jan Beltman
A1 Frederic Goffin
A1 Dimitrios Haidopoulos
A1 Herman Haller
A1 Robert Jach
A1 Iryna Yezhova
A1 Igor Berlev
A1 Margarida Bernardino
A1 Rasiah Bharathan
A1 Maximilian Lanner
A1 Minna M Maenpaa
A1 Vladyslav Sukhin
A1 Jean-Guillaume Feron
A1 Robert Fruscio
A1 Kersti Kukk
A1 Jordi Ponce
A1 María Alonso-Espías
A1 Jose Angel Minguez
A1 Daniel Vázquez-Vicente
A1 Nabil Manzour
A1 Matias Jurado
A1 Teresa Castellanos
A1 Enrique Chacon
A1 Juan Luis Alcazar
YR 2021
UL http://ijgc.bmj.com/content/early/2021/07/28/ijgc-2021-002587.abstract
AB Introduction Comprehensive updated information on cervical cancer surgical treatment in Europe is scarce.Objective To evaluate baseline characteristics of women with early cervical cancer and to analyze the outcomes of the ESGO quality indicators after radical hysterectomy in the SUCCOR database.Methods The SUCCOR database consisted of 1272 patients who underwent radical hysterectomy for stage IB1 cervical cancer (FIGO 2009) between January 2013 and December 2014. After exclusion criteria, the final sample included 1156 patients. This study first described the clinical, surgical, pathological, and follow-up variables of this population and then analyzed the outcomes (disease-free survival and overall survival) after radical hysterectomy. Surgical-related ESGO quality indicators were assessed and the accomplishment of the stated recommendations was verified.Results The mean age of the patients was 47.1 years (SD 10.8), with a mean body mass index of 25.4 kg/m2 (SD 4.9). A total of 423 (36.6%) patients had a previous cone biopsy. Tumor size (clinical examination) <2 cm was observed in 667 (57.7%) patients. The most frequent histology type was squamous carcinoma (794 (68.7%) patients), and positive lymph nodes were found in 143 (12.4%) patients. A total of 633 (54.8%) patients were operated by open abdominal surgery. Intra-operative complications occurred in 108 (9.3%) patients, and post-operative complications during the first month occurred in 249 (21.5%) patients, with bladder dysfunction as the most frequent event (119 (10.3%) patients). Clavien-Dindo grade III or higher complication occurred in 56 (4.8%) patients. A total of 510 (44.1%) patients received adjuvant therapy. After a median follow-up of 58 months (range 0–84), the 5-year disease-free survival was 88.3%, and the overall survival was 94.9%. In our population, 10 of the 11 surgical-related quality indicators currently recommended by ESGO were fully fulfilled 5 years before its implementation.Conclusions In this European cohort, the rate of adjuvant therapy after radical hysterectomy is higher than for most similar patients reported in the literature. The majority of centers were already following the European recommendations even 5 years prior to the ESGO quality indicator implementations.All data relevant to the study are included in the article or uploaded as supplementary information. Data will be available upon the requirement of the reviewers at any time.