RT Journal Article SR Electronic T1 Association of p73 and MDM2 Polymorphisms With the Risk of Epithelial Ovarian Cancer in Chinese Women JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 572-577 OP 572-577 DO 10.1111/IGC.0b013e3181a130ab VO 19 IS 4 A1 Shan Kang A1 Dong-Jie Wang A1 Wan-Sheng Li A1 Na Wang A1 Rong-Miao Zhou A1 Dong-Lan Sun A1 Ya-Nan Duan A1 Shi-Zhen Li A1 Xiao-Fei Li A1 Yan Li YR 2009 UL http://ijgc.bmj.com/content/19/4/572-577.abstract AB Objective: This study was to investigate the association of p73 G4C14-to-A4T14 and Murine Double Minute2 (MDM2) 309T/G, Del1518+/− single nucleotide polymorphisms with the risk of epithelial ovarian cancer (EOC) in Chinese.Materials and Methods: This hospital-based case-control study included 257 ovarian cancer patients and 257 healthy women who were matched for age. p73 and MDM2 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism.Results: There were no significant differences in allele frequencies and genotype distributions of the p73 G4C14-to-A4T14 polymorphism between cases and control women (P = 0.55 and 0.20, respectively). The frequencies of the G allele of the MDM2 309T/G polymorphism were significantly lower in ovarian cancer cases (46.7%) than those in healthy controls (54.7%), there was a statistical difference between the 2 groups (P = 0.01). Compared with the T/T genotype, the G allelotype (T/G+G/G genotype) significantly decreased the risk of developing EOC (odds ratio, 0.65; 95% confidence interval, 0.44-0.97). Although MDM2 Del1518+/− genotypes and allele frequencies did not differ between the case and the control groups (P = 0.68 and P = 0.45), Del1518 +/+ genotype tended to increase the risk of mucinous ovarian cancer or earlier ovarian cancer by stratification analysis according to histological subtypes or clinical stage. Besides, there was a significant interaction between p73 G4C14-to-A4T14 and MDM2 309T/G polymorphisms by the likelihood ratio test (P = 0.03; odds ratio, 0.89; 95% confidence interval, 0.80-0.99).Conclusion: The MDM2 SNP309G allele significantly decreased the risk of EOC and might be a potentially protective factor for EOC development in Chinese women.