TY - JOUR T1 - Association of <em>p73</em> and <em>MDM2</em> Polymorphisms With the Risk of Epithelial Ovarian Cancer in Chinese Women JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 572-577 LP - 572-577 DO - 10.1111/IGC.0b013e3181a130ab VL - 19 IS - 4 AU - Shan Kang AU - Dong-Jie Wang AU - Wan-Sheng Li AU - Na Wang AU - Rong-Miao Zhou AU - Dong-Lan Sun AU - Ya-Nan Duan AU - Shi-Zhen Li AU - Xiao-Fei Li AU - Yan Li Y1 - 2009/04/01 UR - http://ijgc.bmj.com/content/19/4/572-577.abstract N2 - Objective: This study was to investigate the association of p73 G4C14-to-A4T14 and Murine Double Minute2 (MDM2) 309T/G, Del1518+/− single nucleotide polymorphisms with the risk of epithelial ovarian cancer (EOC) in Chinese.Materials and Methods: This hospital-based case-control study included 257 ovarian cancer patients and 257 healthy women who were matched for age. p73 and MDM2 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism.Results: There were no significant differences in allele frequencies and genotype distributions of the p73 G4C14-to-A4T14 polymorphism between cases and control women (P = 0.55 and 0.20, respectively). The frequencies of the G allele of the MDM2 309T/G polymorphism were significantly lower in ovarian cancer cases (46.7%) than those in healthy controls (54.7%), there was a statistical difference between the 2 groups (P = 0.01). Compared with the T/T genotype, the G allelotype (T/G+G/G genotype) significantly decreased the risk of developing EOC (odds ratio, 0.65; 95% confidence interval, 0.44-0.97). Although MDM2 Del1518+/− genotypes and allele frequencies did not differ between the case and the control groups (P = 0.68 and P = 0.45), Del1518 +/+ genotype tended to increase the risk of mucinous ovarian cancer or earlier ovarian cancer by stratification analysis according to histological subtypes or clinical stage. Besides, there was a significant interaction between p73 G4C14-to-A4T14 and MDM2 309T/G polymorphisms by the likelihood ratio test (P = 0.03; odds ratio, 0.89; 95% confidence interval, 0.80-0.99).Conclusion: The MDM2 SNP309G allele significantly decreased the risk of EOC and might be a potentially protective factor for EOC development in Chinese women. ER -