@article {Wang651-656, author = {Yingmei Wang and Fengxia Xue and Russell R. Broaddus and Xia Tao and Su-su Xie and Yanbin Zhu}, title = {Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China}, volume = {19}, number = {4}, pages = {651-656--651-656}, year = {2009}, doi = {10.1111/IGC.0b013e3181a12fb9}, publisher = {BMJ Specialist Journals}, abstract = {Objective: To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China.Methods: Twenty-seven patients who fulfilled Amsterdam criteria II were classified as having Lynch syndrome-associated endometrial carcinoma (group A), and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (group B).Results: There were 81 malignancies in 27 families with Lynch syndrome-associated endometrial carcinoma, including colorectal cancer (24.7\%), endometrial carcinoma (21.0\%), and liver (12.3\%), stomach (9.9\%), lung (6.2\%), and breast (6.2\%) cancers. Mean age at the time of diagnosis was 49.7 years in group A and 56.3 years in group B (P = 0.004). Second primary cancers occurred in 33.3\% of patients in group A and 5.1\% in group B (P = 0.000). The most common second primary cancers were colorectal cancer (44\%) and ovarian cancer (22\%). The percentage of obese patients was higher in group A (P= 0.013). There was no difference between the 2 groups in incidence of diabetes mellitus or hypertension or in histological type and International Federation of Gynecology and Obstetrics stage. The 5-year survival rates for groups A and B were 96.2\% and 79.6\%, respectively. Prognosis for group A was better than for group B (P = 0.045).Conclusions: Some clinicopathological features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. Well-differentiated grade and good prognosis imply better biobehavior of Lynch syndrome-associated endometrial carcinoma in the Chinese population.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/19/4/651-656}, eprint = {https://ijgc.bmj.com/content/19/4/651-656.full.pdf}, journal = {International Journal of Gynecologic Cancer} }