TY - JOUR T1 - Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 713 LP - 720 DO - 10.1136/ijgc-2020-002023 VL - 31 IS - 5 AU - Joanna Baum AU - Elena Ioana Braicu AU - Oliver Hunsicker AU - Ignace Vergote AU - Nicole Concin AU - Els Van Nieuwenhuysen AU - Aarne Feldheiser AU - Patriciu Achimas-Cadariu AU - Silvia Darb-Esfahani AU - Astrid Berger AU - Bogdan Fetica AU - Sven Mahner AU - Andrea Papadia AU - Linn Wölber AU - Maria Luisa Gasparri AU - Adriaan Vanderstichele AU - Pierluigi Benedetti Panici AU - Michael D Mueller AU - Ilary Ruscito AU - Hannah Woopen AU - Jalid Sehouli Y1 - 2021/05/01 UR - http://ijgc.bmj.com/content/31/5/713.abstract N2 - Introduction Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian cancer.Methods Long-term survivors were defined as patients living longer than 8 years after first diagnosis and were recruited within seven high volume centers across Europe from November 1988 to November 2008. The control group included patients with high-grade serous ovarian cancer with less than 5 years' survival identified from the systematic ‘Tumorbank ovarian cancer’ database. A subanalysis of Charité patients only was performed separately for in-depth analysis of tumor dissemination. Propensity score matching with nearest-neighbor caliper width was used to match long-term survivors and the control group regarding age, FIGO stage, and residual tumor.Results A total of 276 patients with high-grade serous ovarian cancer were included, divided into 131 long-term survivors and 145 control group patients. After propensity score matching and multivariable adjustment, platinum sensitivity (p=0.002) was an independent favorable prognostic factor whereas recurrence (p<0.001) and ascites (p=0.021) were independent detrimental predictors for long-term survival. Significantly more long-term survivors tested positive for mutation in the BRCA1 gene than the BRCA2 gene (p=0.016). Intraoperatively, these patients had less tumor involvement of the upper abdomen at initial surgery (p=0.024). Complexity of surgery and surgical techniques were similar in both cohorts.Conclusion Platinum sensitivity constitutes a favorable factor for long-term survival whereas tumor involvement of the upper abdomen, ascites, and recurrence have a negative impact. Based on clinical estimation, long-term survival is associated with combinations of clinical, surgical, and molecular factors.Data are available upon reasonable request. The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified reader. ER -