RT Journal Article
SR Electronic
T1 An immunohistochemical study of the incidence and significance of C-erbB-2 oncoprotein overexpression in ovarian neoplasia
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 285
OP 289
DO 10.1111/j.1525-1438.1991.tb00057.x
VO 1
IS 6
A1 N. WILKINSON
A1 N. TODD
A1 C. H. BUCKLEY
A1 B. A. GUSTERSON
A1 H. FOX
YR 1991
UL http://ijgc.bmj.com/content/1/6/285.abstract
AB An immunohistochemical study was made of overexpression of the c-erbB-2 oncogene product in benign, borderline and malignant epithelial neoplasms of the ovary. Positive staining was found only in 2 of 15 mucinous tumors of borderline malignancy and in 11 of 16 mucinous adenocarcinomas. Positive staining was not detected in serous or endometrioid tumors. Amongst the group of mucinous adenocarcinomas, no correlation could be found between overexpression of c-erbB-2 oncoprotein and tumor stage, tumor differentiation or patient survival. It is concluded that overexpression of c-erbB-2 oncoprotein is not an adverse prognostic factor in ovarian adenocarcinoma.