RT Journal Article
SR Electronic
T1 Ovarian sex cord-stromal tumors: an update on clinical features, molecular changes, and management
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 161
OP 168
DO 10.1136/ijgc-2020-002018
VO 31
IS 2
A1 Rehab Al Harbi
A1 Iain A McNeish
A1 Mona El-Bahrawy
YR 2021
UL http://ijgc.bmj.com/content/31/2/161.abstract
AB Sex cord stromal-tumors are rare tumors of the ovary that include numerous tumor subtypes of variable histological features and biological behavior. Surgery is the main therapeutic modality for the management of these tumors, while chemotherapy and hormonal therapy may be used in some patients with progressive and recurrent tumors. Several studies investigated molecular changes in the different tumor types. Understanding molecular changes underlying the development and progression of sex cord-stromal tumors provides valuable information for diagnostic and prognostic biomarkers and potential therapeutic targets for these tumors. In this review, we provide an update on the clinical presentation, molecular changes, and management of sex cord-stromal tumors.