PT  - JOURNAL ARTICLE
AU  - Al Harbi, Rehab
AU  - McNeish, Iain A
AU  - El-Bahrawy, Mona
TI  - Ovarian sex cord-stromal tumors: an update on clinical features, molecular changes, and management
AID  - 10.1136/ijgc-2020-002018
DP  - 2021 Feb 01
TA  - International Journal of Gynecologic Cancer
PG  - 161--168
VI  - 31
IP  - 2
4099  - http://ijgc.bmj.com/content/31/2/161.short
4100  - http://ijgc.bmj.com/content/31/2/161.full
SO  - Int J Gynecol Cancer2021 Feb 01; 31
AB  - Sex cord stromal-tumors are rare tumors of the ovary that include numerous tumor subtypes of variable histological features and biological behavior. Surgery is the main therapeutic modality for the management of these tumors, while chemotherapy and hormonal therapy may be used in some patients with progressive and recurrent tumors. Several studies investigated molecular changes in the different tumor types. Understanding molecular changes underlying the development and progression of sex cord-stromal tumors provides valuable information for diagnostic and prognostic biomarkers and potential therapeutic targets for these tumors. In this review, we provide an update on the clinical presentation, molecular changes, and management of sex cord-stromal tumors.