PT - JOURNAL ARTICLE AU - Renaud Sabatier AU - Benoît Calderon AU - Eric Lambaudie AU - Elisabeth Chereau AU - Magali Provansal AU - Maria-Antonietta Cappiello AU - Patrice Viens AU - Frederique Rousseau TI - Prognostic Factors for Ovarian Epithelial Cancer in the Elderly: A Case-Control Study AID - 10.1097/IGC.0000000000000418 DP - 2015 Jun 01 TA - International Journal of Gynecologic Cancer PG - 815--822 VI - 25 IP - 5 4099 - http://ijgc.bmj.com/content/25/5/815.short 4100 - http://ijgc.bmj.com/content/25/5/815.full SO - Int J Gynecol Cancer2015 Jun 01; 25 AB - Objectives Ovarian cancer is the leading cause of mortality by gynecologic cancers in Western countries. Many publications have suggested that age may be an independent prognostic factor in ovarian carcinoma. There are only few data concerning the impact of treatments and geriatric features within the elderly population.Methods/Materials We collected data of older (≥70 years old) patients treated in our institution for an invasive ovarian carcinoma between 1995 and 2011. First we described usual clinical and pathological features for these patients, as well as their outcome. We compared these parameters with that of young (<70 years old) patients treated during the same period. We then observed geriatric features in our set: Eastern Cooperative Oncology Group performance status, number of medications, Charlson index, body mass index, hemoglobin, and glomerular filtration rate. We finally looked for prognostic factors specific of the elderly population.Results One hundred nine elderly patients were identified and compared with 488 younger cases. There was no difference concerning clinicopathologic data. Surgery was more frequently complete in young women (58% vs 41.7%), and older patients received less chemotherapy courses and less taxanes (38.4% vs 67.1%). Young patients had a longer overall survival (median, 65.2 vs 26.2 months, P = 8.5E−10, log-rank test). Multivariate analyses confirmed that age was an independent prognostic factor and that within the elderly set the International Federation of Gynecology and Obstetrics stage, surgery results, number of chemotherapy cycles administered and performance status had a significant prognostic value. No clear correlation could be observed between geriatric characteristics and treatments administration.Conclusions Ovarian cancer prognosis is poorer for older women, but they are more frequently suboptimally treated. No correlation could be observed between geriatric factors and surgery or chemotherapy achievement. Treatment decision should be based on objective geriatric assessment in order to improve outcome in this population.