RT Journal Article
SR Electronic
T1 Tubal Ligation and Risk of Endometrial Cancer: Findings From the Women’s Health Initiative
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 464
OP 471
DO 10.1097/IGC.0000000000000651
VO 26
IS 3
A1 Ira Winer
A1 Amy Lehman
A1 Jean Wactawski-Wende
A1 Randal Robinson
A1 Michael Simon
A1 Michele Cote
YR 2016
UL http://ijgc.bmj.com/content/26/3/464.abstract
AB Objective Bilateral tubal ligation (BTL) is a common form of birth control in the United States. There are limited, contradictory data examining BTL and the risk of endometrial cancer and none examining type I and type II cancers separately. We investigated the association between BTL and endometrial cancer risk using the Women’s Health Initiative (WHI) Observational and Dietary Modification Studies.Methods Demographic information and history of BTL were obtained from the baseline questionnaires from 76,483 WHI participants in the Observational and Dietary Modification Studies. Univariable and multivariable models were used to examine the association of BTL with type I and type II endometrial cancers.Results A total of 1137 women were diagnosed with incident endometrial cancer (972 type I and 128 type II) during a mean follow-up of 11.3 years. Overall, 14,499 (19%) women had undergone BTL. There were no statistically significant associations noted between BTL and age at BTL for type I or type II cancers.Conclusions We examined the largest patient cohort to date in an effort to determine the impact of BTL on endometrial cancer risk. In the WHI trial, we observed no overall effect of BTL on the risk of type I or type II endometrial cancer, suggesting that patients undergoing this popular birth control method likely do not have an associated change in their baseline risk for endometrial cancer.