PT  - JOURNAL ARTICLE
AU  - Yu Dong
AU  - Xiaoyun Wang
AU  - Yanan Wang
AU  - Yuan Liu
AU  - Jiawen Zhang
AU  - Wenyan Qian
AU  - Sufang Wu
TI  - Validity of <sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma: A Retrospective Pathology-Matched Study
AID  - 10.1097/IGC.0000000000000287
DP  - 2014 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1642--1647
VI  - 24
IP  - 9
4099  - http://ijgc.bmj.com/content/24/9/1642.short
4100  - http://ijgc.bmj.com/content/24/9/1642.full
SO  - Int J Gynecol Cancer2014 Nov 01; 24
AB  - Objective The aim of this study was to evaluate the validity of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) for pretreatment evaluation of patients with cervical carcinoma.Methods Retrospective evaluation of 63 patients, diagnosed with stage IA-IIA cervical carcinoma who underwent 18F-FDG PET/CT before surgery, was performed. Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios (LRs) of PET/CT for predicting the positive cervix, vagina, uterine body, and lymph node invasion at the surgical specimen was calculated.Results Sensitivity, specificity, positive predictive value, and negative predictive value of the positive cervix invasion in PET/CT to detect positive surgical specimen were 88.2%, 75%, 93.8%, and 60%, respectively. The LR+ ratio was 3.5, and the LR− ratio was 0.2. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive vagina invasion in PET/CT to detect positive surgical specimen were 100%, 70.97%, 5.3%, and 100%, respectively. The LR+ ratio was 3.4, and the LR− ratio was 0. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive uterine body invasion in PET/CT to detect positive surgical specimen were 75%, 83.1%, 23.1%, and 98%, respectively. The LR+ ratio was 4.4, and the LR− ratio was 0.3. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive lymph node invasion in PET/CT to detect positive surgical specimen were 87.5%, 78.4%, 38.9%, and 97.6%, respectively. The LR+ ratio was 4.1, and the LR− ratio was 0.2.Conclusions The cervix invasion, negative uterine body invasion, and negative lymph node invasion are effective 18F-FDG PET/CT findings.