PT - JOURNAL ARTICLE AU - MANUSIRIVITHAYA, S. AU - SRIPRAMOTE, M. AU - TANGJITGAMOL, S. AU - SHEANAKUL, C. AU - LEELAHAKORN, S. AU - THAVARAMARA, T. AU - TANGCHAROENPANICH, K. TI - Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin AID - 10.1136/ijgc-00009577-200411000-00002 DP - 2004 Nov 01 TA - International Journal of Gynecologic Cancer PG - 1063--1069 VI - 14 IP - 6 4099 - http://ijgc.bmj.com/content/14/6/1063.short 4100 - http://ijgc.bmj.com/content/14/6/1063.full SO - Int J Gynecol Cancer2004 Nov 01; 14 AB - To determine whether ginger had antiemetic effect in cisplatin-induced emesis, we conducted a randomized, double-blinded crossover study in 48 gynecologic cancer patients recieving cisplatin-based chemotherapy. Subjects were randomly allocated to regimen A or regimen B in their first cycle of the study. All patients received standard antiemetics in the first day of cisplatin administration. In regimen A, capsules of ginger root powder were given orally 1 g /day for 5 days, starting on the first day of chemotherapy. In regimen B, placebo was given on the first day and metoclopramide was given orally thereafter for 4 days. The patients were then crossed over to receive the other antiemetic regimen in their next cycle of chemotherapy. Among 43 evaluable patients who received both cycles of treatment, success in controls of nausea and emesis were not significantly different between the two regimens in both acute and delayed phases. Restlessness, as a side effect, occurred more often in metoclopramide arm compared to ginger arm (P = 0.109). In conclusion, addition of ginger to standard antiemetic regimen has no advantage in reducing nausea or vomiting in acute phase of cisplatin-induced emesis. In delayed phase, ginger and metoclopramide have no statistically significant difference in efficacy.