PT - JOURNAL ARTICLE AU - E Roser AU - K Pietzner AU - S Brucker AU - P Harter AU - D Zocholl AU - A Gimpel AU - M Kalder AU - M Bossart AU - H Strauß AU - P Wimberger AU - R Armbrust AU - C Marth AU - T Fehm AU - P Jurcikova AU - A Mustea AU - J Sehouli TI - 439 Primary symptoms in women with different histopathological subtypes of gynaecological sarcoma – results of a prospective intergroup registry for gynaecological sarcoma (REGSA – NOGGO RU1) AID - 10.1136/ijgc-2020-IGCS.380 DP - 2020 Nov 01 TA - International Journal of Gynecologic Cancer PG - A182--A182 VI - 30 IP - Suppl 3 4099 - http://ijgc.bmj.com/content/30/Suppl_3/A182.1.short 4100 - http://ijgc.bmj.com/content/30/Suppl_3/A182.1.full SO - Int J Gynecol Cancer2020 Nov 01; 30 AB - Introduction Gynaecological sarcomas are rare and there is very limited evidence about symptoms at primary diagnosis. Most knowledge is based on retrospective analysis.Methods We present data of 410 patients (pts) in the primary situation. Overall, 87.91% of pts had documented symptom data, which were analysed descriptively. A distinction was made between pre- (prem., ≤52 yrs) and postmenopausal (postm., >52 yrs.).Results The average age of pts was 56 yrs (range 15–88 yrs). Leiomyosarcoma (LMS) was diagnosed in 44.7%, endometrial stromal sarcoma (ESS) in 26.6% (62.6% low grade (LG-ESS) and 37.4% high grade (HG-ESS)). Undifferentiated sarcoma (US) and adenosarcoma (AS) were observed in 5.7% and 8.7% respectively. In prem. and postm. pts with LMS, the leading symptom (LS) was abdominal pain (ap) in 34.4%. and 39.5% respectively. In prem. HG-ESS the LS were ap and bleeding disorders (bd) in both 33.3%. In postm. HG-ESS and prem. LG-ESS the LS was vaginal bleeding (vb) in 29% and 33.3% respectively. In prem. AS the LS was ap in 27.3%, whereas in postm. AS it was postmenopausal bleeding (pb) in 29.2%. In prem. US the LS were bd and vb both at 66.7%. In postm. US the LS was ap in 47.4%.Conclusions We analyzed the LS of different histopathological subtypes in primary gynaecological sarcoma for the first time. Bleeding disorders and abdominal pain are the main symptoms in all subtypes. Symptoms are heterogeneous and about every 5th woman reported unspecific symptoms. This underlines the importance of awareness for gynaecological sarcoma.