RT Journal Article
SR Electronic
T1 30 Risk factors associated with increasing incidence of uterine cancer after correcting for hysterectomy
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A21
OP A22
DO 10.1136/ijgc-2020-IGCS.30
VO 30
IS Suppl 3
A1 C Liao
A1 K Tran
A1 M Richardson
A1 K Darcy
A1 C Tian
A1 CA Hamilton
A1 L Maxwell
A1 A Mann
A1 DS Kapp
A1 JK Chan
YR 2020
UL http://ijgc.bmj.com/content/30/Suppl_3/A21.abstract
AB Objective To evaluate the demographic factors associated with the increase in incidence of uterine cancer after correcting for hysterectomy.Methods From 2001–2016, incidence rates of uterine cancers (epithelial carcinoma and sarcomas) were estimated from United States Cancer Statistics after correcting for hysterectomy prevalence based on Behavioral Risk Factor Surveillance System data. SEER*Stat and Joinpoint regression were used to calculate incidence rate (per 100,000) and average annual percent change (AAPC).Results Of 720,984 patients, 78% White, 10% Black, 8% Hispanic, and 3% Asian/Pacific-Islander. After correcting for hysterectomy, the estimated incidence increased from 27.1 to 42/100,000 women. Over 15 years, the incidence increased from 40.8 to 42.9 with an annual percent increase (AAPC) of 0.5% per year (p<0.05). The 65–69 year old group had the highest incidence (185.4). With respect to race, the highest baseline incidence was in Blacks at 49.5 that increased 2.3% per year (AAPC). Whites had an incidence of 43.6 with an annual percent increase of only 0.4%. The Hispanics had an incidence of 35.0 (AAPC=1.1%), then Asians incidence 24.0 (AAPC=1.3%). The intersectionality of age and race showed that the group with the highest risk was 65–69 year old and Black with an incidence of 281.1 (AAPC=2.3%).Abstract 30 Figure 1 Abstract 30 Figure 2 Conclusion The intersectionality of age and race found age 65–69 Black women with the highest incidence of uterine cancer with a six-fold increase compared to the general population, using hysterectomy-corrected data. Further studies are warranted to determine potential genetic, social-determinant, or environment exposures to explain these findings.